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Living Donor Selection Criteria

Eligibility Criteria

• Excellent overall health
• Age 18 or older
• BMI less than or equal to 35
• Contraindications to Living Kidney Donation

Absolute Contraindications

• Medical
  • Significant coronary artery disease
  • Symptomatic valvular disease without correction
  • Significant peripheral arterial disease or carotid artery stenosis.
  • History of hypertension and age < 50 years old
  • Moderate or severe chronic lung disease
  • Creatinine clearance < 80 mL/min/1.73m2
  • Diabetes mellitus
  • Microalbuminuria > 100mg/24hr
  • History of chronic kidney disease (e.g., glomerulonephritis, nephrocalcinosis)
  • Sickle cell disease
  • Active sarcoidosis
• Infection
  • HIV infection
  • Active hepatitis B or hepatitis C infection
• Malignancy
  • History of melanoma
• Financial/social
  • Severe psychiatric illness
  • Alcohol abuse, or recent use (6 months) of cocaine, amphetamines, non-prescription opiates, any IV drugs, bath salts
  • Incarceration or home arrest

Relative Contraindications

• Medical
  • Hypertension
  • Active use of medications that may cause kidney dysfunction
  • History of thrombosis or embolism
  • Urologic abnormalities of donor kidney
  • Nephrolithiasis (recurrent)
  • Impaired glucose tolerance
  • Autoimmune disease
  • Sickle cell trait
  • Creatinine clearance 80-90 mL/min/1.73m²
  • Microalbuminuria 30-100mg/24hr
• Malignancy
  • History of non-cutaneous malignancy
• Financial/social
  • Refusal to receive blood products
  • Currently serving parole or on probation.

Disease specific notes

Polycystic kidney disease: Refer to UMMC policy on PKD in potential donors

Nephrolithiasis: Potential donors with a history of kidney stones will undergo complete metabolic testing with serum iPTH testing and 24 hour urine stone risk assessment via Litholink. Determination of donor acceptance will be based on a donor-specific assessment of current stone burden and risk of stone recurrence.